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Sanzio Candeletti Selected Research

Nociceptin

1/2018The standardized Withania somnifera Dunal root extract alters basal and morphine-induced opioid receptor gene expression changes in neuroblastoma cells.
8/2015A new potent analgesic agent with reduced liability to produce morphine tolerance.
5/2015Combined exposure to agriculture pesticides, paraquat and maneb, induces alterations in the N/OFQ-NOPr and PDYN/KOPr systems in rats: Relevance to sporadic Parkinson's disease.
5/2013Different alcohol exposures induce selective alterations on the expression of dynorphin and nociceptin systems related genes in rat brain.
2/2012∆(9)-Tetrahydrocannabinol decreases NOP receptor density and mRNA levels in human SH-SY5Y cells.
8/2010Brain interstitial nociceptin/orphanin FQ levels are elevated in Parkinson's disease.
3/2009Alterations of N/OFQ and NOP receptor gene expression in the substantia nigra and caudate putamen of MPP+ and 6-OHDA lesioned rats.
6/2008Kainic acid down-regulates NOP receptor density and gene expression in human neuroblastoma SH-SY5Y cells.
10/2006Nociceptin levels in the cerebrospinal fluid of chronic pain patients with or without intrathecal administration of morphine.
10/2005Blockade of nociceptin/orphanin FQ transmission attenuates symptoms and neurodegeneration associated with Parkinson's disease.
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Sanzio Candeletti Research Topics

Disease

10Neuroblastoma
01/2018 - 06/2008
9Pain (Aches)
10/2021 - 10/2006
5Neuralgia (Stump Neuralgia)
01/2022 - 04/2017
5Chronic Pain
01/2022 - 10/2006
5Parkinson Disease (Parkinson's Disease)
11/2015 - 10/2005
3Alcoholism (Alcohol Abuse)
01/2017 - 02/2013
3Seizures (Absence Seizure)
06/2008 - 11/2002
2Cancer Pain
01/2022 - 04/2017
2Alzheimer Disease (Alzheimer's Disease)
05/2016 - 09/2015
2Parkinsonian Disorders (Parkinsonism)
08/2010 - 10/2005
1Opioid-Related Disorders (Opiate Addiction)
01/2022
1Neoplasms (Cancer)
01/2022
1Respiratory Insufficiency (Respiratory Failure)
01/2022
1Painful Neuropathy
11/2021
1Fabry Disease (Fabry's Disease)
10/2021
1Hypersensitivity (Allergy)
02/2021
1Colorectal Neoplasms (Colorectal Cancer)
12/2020
1Hyperalgesia
12/2020
1Opioid-Induced Constipation
01/2020
1Chronic Kidney Failure (Chronic Renal Failure)
01/2020
1Chronic Renal Insufficiency
01/2020
1Substance Withdrawal Syndrome (Withdrawal Symptoms)
12/2019
1Nociceptive Pain
02/2019
1Acute Pain
02/2019
1Serotonin Syndrome (Syndrome, Serotonin)
02/2019
1Rheumatoid Arthritis
04/2017
1Low Back Pain (Lumbago)
04/2017
1Osteoarthritis
04/2017
1Body Weight (Weight, Body)
12/2016
1Substance-Related Disorders (Drug Abuse)
04/2016
1Nervous System Diseases (Neurological Disorders)
09/2015
1Cognitive Dysfunction
09/2015
1Neurodegenerative Diseases (Neurodegenerative Disease)
05/2015
1Bipolar Disorder (Manic Depressive Psychosis)
06/2012
1Psychotic Disorders (Schizoaffective Disorder)
06/2012
1Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental)
02/2011
1Multiple Sclerosis
02/2011

Drug/Important Bio-Agent (IBA)

12NociceptinIBA
01/2018 - 11/2002
11Opioid Analgesics (Opioids)IBA
01/2022 - 10/2005
5Analgesics (Analgesic Drugs)IBA
01/2022 - 08/2015
5NeuropeptidesIBA
08/2019 - 11/2002
5Morphine (MS Contin)FDA LinkGeneric
03/2019 - 10/2006
4Fentanyl (Sublimaze)FDA LinkGeneric
01/2020 - 10/2013
4Opioid Receptors (Opioid Receptor)IBA
01/2018 - 08/2014
3Messenger RNA (mRNA)IBA
10/2021 - 11/2002
3Ethanol (Ethyl Alcohol)IBA
02/2021 - 03/2011
3preproenkephalinIBA
12/2020 - 03/2011
3Proteasome Endopeptidase Complex (Proteasome)IBA
12/2020 - 11/2015
3TapentadolFDA Link
01/2020 - 08/2014
3Brain-Derived Neurotrophic Factor (BDNF)IBA
05/2016 - 06/2012
3Nociceptin ReceptorIBA
08/2010 - 11/2002
3Kainic Acid (Kainate)IBA
06/2008 - 11/2002
2Buprenorphine (Subutex)FDA LinkGeneric
01/2022 - 01/2020
2EnzymesIBA
11/2021 - 10/2021
2Proteasome InhibitorsIBA
12/2020 - 03/2019
2Proteins (Proteins, Gene)FDA Link
12/2020 - 09/2015
2Neurotransmitter Agents (Neurotransmitter)IBA
10/2020 - 08/2019
2AcetaldehydeIBA
01/2017 - 03/2011
2Sirtuin 1IBA
05/2016 - 09/2015
2Pharmaceutical PreparationsIBA
04/2016 - 09/2015
2ManebIBA
11/2015 - 05/2015
2ParaquatIBA
11/2015 - 05/2015
1AerosolsIBA
01/2022
16'- fluoro- 4',9'- dihydro- N,N- dimethyl- 4- phenylspiro(cyclohexane- 1,1'(3'H)- pyrano(3,4- b)indol)- 4- amineIBA
01/2022
1SmokeIBA
01/2022
1CytokinesIBA
11/2021
1GlycosphingolipidsIBA
10/2021
1GalactosidasesIBA
10/2021
1ONX 0912IBA
12/2020
1Antineoplastic Agents (Antineoplastics)IBA
12/2020
1UbiquitinIBA
12/2020
1Oxaliplatin (Eloxatin)FDA LinkGeneric
12/2020
1G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA
10/2020
1MelatoninIBA
10/2020
1MT2 Melatonin ReceptorIBA
10/2020
1Narcotic Antagonists (Opioid Antagonists)IBA
01/2020
1NicotineFDA Link
12/2019
1Heroin (Diamorphine)IBA
03/2019
1Serotonin (5 Hydroxytryptamine)IBA
02/2019
1Hormones (Hormone)IBA
02/2019
1N-Methyl-3,4-methylenedioxyamphetamine (MDMA)IBA
12/2016
1Peptides (Polypeptides)IBA
05/2016
1Amyloid (Amyloid Fibrils)IBA
05/2016
1ATP dependent 26S protease (26S proteasome)IBA
04/2016
1Cocaine (Cocaine HCl)IBA
04/2016
1Tyrosine 3-Monooxygenase (Tyrosine Hydroxylase)IBA
11/2015
1SynucleinsIBA
11/2015
1Biomarkers (Surrogate Marker)IBA
09/2015
114-O-methylmorphine-6-O-sulfateIBA
08/2015
1Environmental Pollutants (Pollutants, Environmental)IBA
05/2015
1Agrochemicals (Agricultural Chemicals)IBA
05/2015
1Dynorphins (Dynorphin)IBA
05/2013
1CannabinoidsIBA
02/2011
1Complex MixturesIBA
02/2011

Therapy/Procedure

5Therapeutics
01/2022 - 10/2005
1Transjugular Intrahepatic Portasystemic Shunt
01/2020
1Renal Dialysis (Hemodialysis)
01/2020
1Analgesia
03/2019
1Self Administration (Administration, Self)
03/2019
1Deep Brain Stimulation
08/2010